Selective Delivery of Pentamidine to the Lung by Aerosol
作者： A. Bruce Montgomery , Robert J. Debs , John M. Luce , Kevin J. Corkery , Joan Turner
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摘要: In 8 patients with diffuse infiltrates on chest radiograph undergoing fiberoptic bronchoscopy for suspected Pneumocystis carinii pneumonia, bronchoalveolar lavage sediment and supernatant concentrations of pentamidine were compared 18 to 24 h after administration 4 mg/kg intravenous (n = 3) aerosolized 5) isethionate. Aerosol was inhaled 35 40 min 300 mg isethionate in a jet nebulizer, baffled decrease the particle size 1.42 µm ± 1.88 (mass median aerodynamic diameter geometric standard deviation). Bronchoalveolar were: sediment, 9.34 1.74 postintravenous versus 705 242 ng/ml postaerosol (mean SEM, p < 0.05); supernatant, 2.64 0.73 23.2 7.75 0.05). Serum levels low or undetectable aerosolization. delivers significantly higher air spaces than does delivery in...
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