Therapeutic nanomedicine for brain cancer

作者: Stephany Y Tzeng , Jordan J Green

DOI: 10.4155/TDE.13.38

关键词:

摘要: Malignant brain cancer treatment is limited by a number of barriers, including the blood-brain barrier, transport within interstitium, difficulties in delivering therapeutics specifically to tumor cells, highly invasive quality gliomas and drug resistance. As result, prognosis for patients with high-grade poor has improved little recent years. Nanomedicine approaches have been developed laboratory, some technologies being translated clinic, order address these needs. This review discusses obstacles effective that are currently faced field, as well various nanomedicine techniques used or explored overcome them, focus on liposomal polymeric nanoparticles.

参考文章(141)
Marie Blanchette, David Fortin, Blood-Brain Barrier Disruption in the Treatment of Brain Tumors Methods in Molecular Biology. ,vol. 686, pp. 447- 463 ,(2011) , 10.1007/978-1-60761-938-3_23
Tore Bach-Gansmo, Ferrimagnetic susceptibility contrast agents. Acta Radiologica. ,vol. 387, pp. 1- 30 ,(1993)
Christine J Hawkins, TRAIL and Malignant Glioma TRAIL (TNF-Related Apoptosis-Inducing Ligand). ,vol. 67, pp. 427- 452 ,(2004) , 10.1016/S0083-6729(04)67022-1
Xing Wu, Jin Hu, Liangfu Zhou, Ying Mao, Bojie Yang, Liang Gao, Rong Xie, Feng Xu, Dong Zhang, Jun Liu, Jianhong Zhu, In vivo tracking of superparamagnetic iron oxide nanoparticle-labeled mesenchymal stem cell tropism to malignant gliomas using magnetic resonance imaging Laboratory investigation Journal of Neurosurgery. ,vol. 108, pp. 320- 329 ,(2008) , 10.3171/JNS/2008/108/2/0320
Matthew J. McGirt, Khoi D. Than, Jon D. Weingart, Kaisorn L. Chaichana, Frank J. Attenello, Alessandro Olivi, John Laterra, Lawrence R. Kleinberg, Stuart A. Grossman, Henry Brem, Alfredo Quiñones-Hinojosa, Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme Journal of Neurosurgery. ,vol. 110, pp. 583- 588 ,(2009) , 10.3171/2008.5.17557
A.G. de Boer, I.C.J. van der Sandt, P.J. Gaillard, THE ROLE OF DRUG TRANSPORTERS AT THE BLOOD-BRAIN BARRIER Annual Review of Pharmacology and Toxicology. ,vol. 43, pp. 629- 656 ,(2003) , 10.1146/ANNUREV.PHARMTOX.43.100901.140204
Anu-Maaria Sandmair, Sami Loimas, Paula Puranen, Arto Immonen, Maija Kossila, Matti Puranen, Heleena Hurskainen, Kristiina Tyynelä, Marita Turunen, Ritva Vanninen, Pauliina Lehtolainen, Leo Paljärvi, Risto Johansson, Matti Vapalahti, Seppo Ylä-Herttuala, Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses. Human Gene Therapy. ,vol. 11, pp. 2197- 2205 ,(2000) , 10.1089/104303400750035726
Michal T. Krauze, Charles O. Noble, Tomohiro Kawaguchi, Daryl Drummond, Dmitri B. Kirpotin, Yoji Yamashita, Erika Kullberg, John Forsayeth, John W. Park, Krystof S. Bankiewicz, Convection-enhanced delivery of nanoliposomal CPT-11 (irinotecan) and PEGylated liposomal doxorubicin (Doxil) in rodent intracranial brain tumor xenografts Neuro-oncology. ,vol. 9, pp. 393- 403 ,(2007) , 10.1215/15228517-2007-019