In vivo tracking of superparamagnetic iron oxide nanoparticle-labeled mesenchymal stem cell tropism to malignant gliomas using magnetic resonance imaging Laboratory investigation
作者： Xing Wu , Jin Hu , Liangfu Zhou , Ying Mao , Bojie Yang
DOI: 10.3171/JNS/2008/108/2/0320
关键词:
摘要: Object Mesenchymal stem cells (MSCs) have been shown to migrate toward tumors, but their distribution pattern in gliomas has not completely portrayed. The primary purpose of the study was assay tropism capacity MSCs gliomas, delineate MSC after systemic injection, and track migration incorporation magnetically labeled using 1.5-T magnetic resonance (MR) imaging. Methods from Fischer 344 rats were colabeled with superparamagnetic iron oxide nanoparticles (SPIO) enhanced green fluorescent protein (EGFP). quantitatively assayed vitro Transwell system. To vivo, MR imaging performed both 7 14 days administration MSCs. After imaging, patterns examined Prussian blue fluorescence staining. Results showed that possessed signific...
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