Glioma Tropic Neural Stem Cells Consist of Astrocytic Precursors and Their Migratory Capacity Is Mediated by CXCR4

摘要: Malignant gliomas spawn disseminated microsatellites, which are largely refractory to currently employed therapies, resulting in eventual tumor recurrence and death. The use of tumor-tropic neural stem cells (NSCs) as delivery vehicles for therapeutic gene products represents an attractive strategy specifically focused at treating these residual neoplastic foci. We wished elucidate the biological cues governing NSC tropism glioma. In this context, we describe that NSCs comprise astrocytic progenitors expressing chemokine receptor 4 (CXCR4). Blocking CXCR4 significantly inhibits migration toward tumor. These findings define specific characteristics associated with cell populations within transplanted demonstrate glioma-tracking behavior.