Migratory neural stem cells for improved thymidine kinase-based gene therapy of malignant gliomas
作者： Martin Uhl , Markus Weiler , Wolfgang Wick , Andreas H. Jacobs , Michael Weller
DOI: 10.1016/J.BBRC.2004.12.164
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摘要: Abstract Gene therapy of glioma based on viral delivery herpes simplex virus type I thymidine kinase (HSV-TK) has failed in the clinic because low transduction efficacy. To circumvent this problem, study evaluated highly migratory HSV-TK-transduced neural stem cells (NSC) for their ability to kill untransduced by a gap junction-mediated bystander effect. The admixture NSC U87MG and LN-18 human malignant cell lines at ratios 1:10 or 1:1 eliminated more than 50% 90% presence ganciclovir (25 μM). Glioma cytotoxicity required cell–cell contact. Similarly, tumor was observed two three primary glioblastoma cultures, effect correlated with expression connexin 43 target cells. In conclusion, we delineate role HSV-transfected eliminate purely means
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