Pain: Antidepressant, Anticonvulsants
作者： J. Markman , S. Nohria
DOI: 10.1016/B978-0-12-385157-4.00215-3
关键词:
摘要: Increasing appreciation for the analgesic efficacy of certain antidepressant and anticonvulsant drugs has culminated in their widespread use chronic pain indications. Dozens randomized controlled clinical trials patients without depression or epilepsy have propelled (referred to as ‘adjuvants’) such amitriptyline, gabapentin, duloxetine become most widely used agents after nonsteroidal anti-inflammatory (NSAIDs) opioids. Initially, these were studied with painful diabetic neuropathy postherpetic neuralgia. Recently, pain-relieving benefit shared putative mechanisms supraspinal inhibition reuptake norepinephrine extended populations fibromyalgia low back pain.
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