Gabapentin for chronic neuropathic pain and fibromyalgia in adults

作者: R Andrew Moore , Philip J Wiffen , Sheena Derry , Henry J McQuay

DOI: 10.1002/14651858.CD007938.PUB2

关键词:

摘要: Neuropathic pain is coming from damaged nerves. It differs messages carried along healthy nerves tissue (a fall, cut, or arthritic knee). treated by different medicines than tissue. Medicines like paracetamol ibuprofen are not effective in neuropathic pain, while that sometimes used to treat depression epilepsy can be very some people with pain. Our understanding of fibromyalgia condition persistent, widespread and tenderness, sleep problems, fatigue) poor, but respond the same as pain. Gabapentin was developed epilepsy, it now various forms chronic On 17 March 2014 we performed searches look for clinical trials where gabapentin fibromyalgia. We found 5633 participants had been involved 37 studies reasonable quality. They tested against placebo four weeks more. Studies lasting only one two unhelpful when last years. Only conditions useful amounts data - postherpetic neuralgia (chronic following shingles) painful diabetic neuropathy (where diabetes). Gabapentin helped 3 4 10 reducing their at least half, 2 this result. With 6 expect have adverse events, including dizziness (2 10), somnolence (1 peripheral oedema gait disturbance 10). Serious events 33) were no more common placebo. One person withdrew because events. Persons taking event (6 stop an (about 1 10). Gabapentin helpful possible know beforehand who will benefit not. Current knowledge suggests a short trial best way telling.

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