Depression of the electroretinogram in rats deficient in zinc and taurine during prenatal and postnatal life

摘要: The objective of this study was to investigate whether zinc interacts with taurine influence the development electroretinogram. Virgin female Sprague-Dawley rats were bred overnight and assigned 1 4 treatments in a 2 × factorial design two levels (50 μg/g through gestation 50 after parturition; 15 7.5 parturition) (2 or 0 μmol/g). Guanidinoethyl sulfonate (10 g/L), structural analogue taurine, added drinking water animals receiving μmol/g taurine. At postnatal day 23, male pups (n = 10) weaned onto their respective diets. Dark-adapted electroretinograms recorded as function stimulus intensity on 7 1/2–8 1/2-week-old anesthetized pups. Two-factor analysis variance demonstrated no interaction between for a- b-wave amplitudes latencies (P < 0.05). Zinc deficiencies each independently depressed electroretinogram a-wave but not latencies. amplitude plotted log intensity, an iterative curve-fitting procedure used determine maximum response, slope, half-saturation constant. No noted. A significant treatment effect response 0.0498) 0.0014). effects evident constant slope. These findings indicate that are synergistic depressing model.