Chemosensitization of tumor cells: inactivation of nuclear factor-kappa B associated with chemosensitivity in melanoma cells after combination treatment with E2F-1 and doxorubicin.

摘要: Combination chemotherapy has been shown to be more effective than single-agent therapy for many types of cancer, but both are known induce drug resistance in cancer cells. Two major culprits the development this nuclear factor-kappaB (NF-kappaB) and multidrug (MDR) gene. For reason, chemogene is emerging as a viable alternative conventional combinations. We have that transduction E2F-1 gene melanoma cells markedly increases cell sensitivity doxorubicin, thereby producing synergistic effect on apoptosis. Our microarray results show NF-kappaB pathway related genes undergo significant changes after combined treatment doxorubicin. In fact, inactivation associated with apoptosis induced by providing link between signaling chemosensitivity treatment.