摘要: The pathogenetic mechanisms behind Helicobacter pylori-associated morbidity have so far not been fully elucidated1. It has proposed that H. pylori contributes to gastroduodenal injury either by impairing local mucosal defence2 or increasing antral gastrin release, which leads increased gastric acidity3. ‘leaking roof’ theory — impaired defence related many inflammatory and toxic factors1. One of these could be acetaldehyde produced alcohol dehydrogenase (HPADH).
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