Effect of the ACE inhibitor lisinopril on mortality in diabetic patients with acute myocardial infarction: data from the GISSI-3 study.

摘要: Background Mortality of diabetic patients with acute myocardial infarction (MI) remains high despite recent improvement in their management. There is a need to evaluate efficacy and safety novel treatments MI this high-risk population. We evaluated whether treatment an ACE inhibitor begun within 24 hours from the onset symptoms able decrease mortality morbidity MI. Methods Results A retrospective analysis data GISSI-3 study without history diabetes was performed. Patients suspected were randomized lisinopril (2.5 5 up 10 mg/d) or nitroglycerin (5 20 μg IV then continued for 6 weeks. The main end point at weeks, secondary combined evaluation severe left ventricular dysfunction. Information on status available 18 131 (≈94% total p...