Mutational Pattern in Multiple Pulmonary Nodules Are Associated With Early Stage Lung Adenocarcinoma.

摘要: The clinical significance of mutation in multiple pulmonary nodules is largely limited by single gene mutation-directed analysis and lack validation expression profiles. New analytic strategy urgently needed for comprehensive understanding genomic data nodules. In this study, we performed whole exome sequencing 16 lung 5 adjacent normal tissues from 4 patients with decoded the information a perspective cellular functions signaling pathways. Mutated genes as well patterns shared more than two lesions were identified characterized. We found that number mutations or mutated extent protein structural changes caused different positively correlated degree malignancy. Moreover, are associated molecular pathways related to cell proliferation survival. showed developing pattern quantity (the mutations/mutated genes) quality changes) survival This study provides new comprehension mutational might shed light on deciphering evolution early stage adenocarcinoma.