Symptoms of myasthenia gravis in a patient with a history of thymectomy for invasive thymoma

摘要: Introduction: Myasthenia gravis is an antibody-mediated autoimmune disease. Approximately 10-15% of patients present with a thymoma, the presence which associated greater severity symptoms, myasthenic crisis, and irresponsiveness to front-line therapy. A thymectomy recommended in young generalized myasthenia all presenting thymoma. Clinical case: The patient was 43-year-old woman, who first showed symptoms crisis 2005 presented invasive thymoma managed radiotherapy. In subsequent three years, severe two crises that required mechanical ventilation immunoglobulin treatment. Contrast chest computed tomography examinations no recurrence. Between 2009 2012, experienced decreased symptom severity. 2013, exacerbation symptoms; contrast magnetic resonance scan lesion anterior mediastinum, previously observed 2011, suggestive residual tissue as opposed fibrosis. Regular management started immunoglobulins; positron emission inconclusive, requiring new resection, evidence tumor Conclusions: Patients those myasthenia-related both share element However, following procedure, or reappearance does not necessarily represent alterations thymus.