Genetics of Renal Hypoplasia: Insights Into the Mechanisms Controlling Nephron Endowment

摘要: Renal hypoplasia, defined as abnormally small kidneys with normal morphology and reduced nephron number, is a common cause of pediatric renal failure adult-onset disease. Genetic studies performed in humans mutant mice have implicated number critical genes, utero environmental factors molecular mechanisms that regulate endowment kidney size. Here, we review current knowledge regarding the genetic contributions to hypoplasia particular emphasis on control mice.