Health benefits of higher serum 25-hydroxyvitamin D levels in The Netherlands

摘要: A large and rapidly expanding body of scientific literature exists on the roles vitamin D in maintaining optimal health reducing risk chronic infectious diseases. Serum 25-hydroxyvitamin [25(OH)D] levels for are range 100–150 nmol/L; mean population values The Netherlands around 50–63 nmol/L. Health problems which there good observational evidence some randomized controlled trial that reduces include many types cancer, cardiovascular disease, diabetes mellitus, bacterial viral infections, autoimmune diseases, osteoporosis, falls fractures, dementia, congestive heart failure, adverse pregnancy outcomes. Reductions incidence mortality rates various diseases all-cause can be determined from ecological, cross-sectional studies trials. For Netherlands, raising serum 25(OH)D to 105 nmol/L is estimated reduce specific disease by 10–50% 18%. To raise this amount, inhabitants would have increase production or oral intake 2500–4000 IU/day. Doing so pose only minimal increased risks melanoma skin cancer hypercalcemia.