Non-hormonal and hormonal control of glycogen metabolism in isolated sheep liver cells.
作者： Christine Morand , Catherine Redon , Christian Remesy , Christian Demigne
DOI: 10.1016/0020-711X(90)90291-A
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摘要: Abstract 1. Control of glycogen metabolism by various substrates and hormones was studied in ruminant liver using isolated hepatocytes from fed sheep. 2. In these cells glucose appeared uneffective to stimulate synthesis whereas fructose propionate activated synthase owing (i) a decrease phosphorylase activity (ii) changes the intracellular concentrations 6-phosphate adenine nucleotides. 3. The activation hepatic glycogenolysis glucagon α 1 -adrenergic agents associated with increased decreased activities. 4. simultaneous two enzyme activities suggest that sheep liver, is not prerequisite step for inactivation. 5. hepatocytes, presence after lag period, insulin without affecting . 6. This latter result suggests direct mediated synthase-specific kinase or phosphatase. Insulin also antagonized effect on counteracting rise cAMP.
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