A Comprehensive Computer Program For The Study Of Drug Release Kinetics From Compressed Matrices

摘要: The article presents details of ZOREL, a software developed for the purpose studying drug release kinetics from compressed matrics. program, written in FORTRAN, uses raw dissolution data input. It initially corrects and/or volume losses occurring at time sampling and on basis weight dosage form content, estimates values amount percent released various times each formulation unit. log mean fraction are computed regressed against to yield kinetic constant (k) exponent (n) subsequently calculations made (MDT). For swelling matrices, respective contributions diffusion polymer relaxation along with constants k1 k2, also computed. Based phenomenological analysis, predicts type viz Fickian, non-Fickian (anomalous) or zero-order. In addition, (±SD) calculated square root up observations. rate release, t50%, t60%, t90% using program.