Long-term sequelae of Pneumococcal Sepsis in children: a systematic review

摘要: ABSTRACT Background Long-term sequelae associated with pneumococcal sepsis (PS) in pediatric patients existing literature is currently unclear. Aim To review the evidence on and prognostic factors PS among patients. Method We conducted a systematic following Preferred Reporting Items for Systematic Reviews Meta-Analyses reporting guidelines. screened six databases from their inception to January 15, 2021. Study population were neonates, infants, children adolescents less than 18 years old suspected or confirmed disease. Outcomes included types, factors, pooled death estimate length of hospital stay (LOS) survivors deceased Quality studies was assessed using Joanna Briggs Institute appraisal checklists. Results 981 abstracts, 24 full-text articles final review. Septic shock most prevalent physical reported (13%, n=1492 patients). No functional, cognitive neurological studies. Meta-analysis mortality 14.6% (95%CI: 9.9 −19.4%). Prognostic increased risk score ≥ 10 co-infection meningitis. LOS non-survivors ranged between 5-30 days 1-30 days. Nine met at least 50% quality assessment criteria. Conclusion Physical are types identified literature. Lack information about other possible suggests long-term consequences disease maybe underreported, especially resource-limited settings. Future should consider exploring reasons this knowledge gap.