Anti-cell Proliferative, Anti-inflammatory and Anti-angiogenic Potential of Lupeol in 7,12-dimethylbenz(a) Anthracene Induced Hamster Buccal Pouch Carcinogenesis
作者： Asokan Manimaran , Shanmugam Manoharan , Sekar Karthikeyan , Madavan Nirmal
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摘要: Aim: Diverse pharmacological and biochemical effects of lupeol have been reported earlier. The present study utilized the immune expression pattern proliferating cellular nuclear antigen (PCNA), cyclin D1, vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2) kappa B (NFkB) to assess anticancer potential in 7,12-dimethylbenz(a) anthracene (DMBA) induced oral carcinogenesis. Methods: Well differentiated squamous cell carcinoma was appeared buccal mucosa hamsters painted with DMBA thrice a week for 14 weeks. molecular Original Research Article Manimaran et al.; BJMMR, 6(6): 587-596, 2015; no.BJMMR.2015.236 588 markers analysed using immunohistochemistry (PCNA, VEGF), Real Time PCR (NFkB, D1) ELISA (COX-2). Results: We noticed tumors all treated alone thus tumor incidence is 100%. total number developed 23. Upregulation proliferative D1), inflammatory COX-2) angiogenic (VEGF) bearing hamsters. Lupeol administration orally completely inhibited formation (0%) downregulated immunoexpression (VEGF). Conclusion: results suggest that exhibited antitumor through its anticell proliferative, anti-inflammatory anti-angiogenic during
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