Cell cycle-regulatory cyclins and their deregulation in oral cancer
DOI: 10.1016/J.ORALONCOLOGY.2013.01.008
关键词: Cancer research 、 Biology 、 Cyclin D 、 Cell cycle 、 Cyclin A 、 Cell biology 、 Cyclin A2 、 Cyclin E 、 Cyclin 、 Cancer 、 Carcinogenesis
摘要: Oral cancer is a growth-related disorder, and cyclins are the prime regulators of cell division. Cyclins associated with pathogenesis oral considered valuable biomarkers for diagnosis prognosis. These important molecules regulated in many ways to achieve gain function involved promoting neoplastic growth. While causes most cyclin overexpression varied, these may be induced by buccal mucosal insult mainly carcinogens that alter various pathways propelling cancer. Substantial experimental evidences support link between oncogenic signaling deregulation This review focuses on mechanisms which promote oncogenesis.
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