Profiling walking dysfunction in multiple sclerosis: characterisation, classification and progression over time.

摘要: Gait dysfunction is a common and relevant symptom in multiple sclerosis (MS). This study aimed to profile gait pathology gait-impaired patients with MS using comprehensive 3D analysis clinical walking tests. Thirty-seven walked on the treadmill at their individual, sustainable speed while 20 healthy control subjects all different patient’s paces, allowing for comparisons independent of velocity. Kinematic revealed pronounced restrictions knee ankle joint excursion, increased variability asymmetry along impaired dynamic stability patients. The most discriminative single parameter, differentiating from controls an accuracy 83.3% (χ2 test; p = 0.0001), was reduced range motion. Based hierarchical cluster principal component analysis, three pathological patterns were identified: spastic-paretic, ataxia-like, unstable gait. Follow-up assessments after 1 year indicated deterioration function, particularly spastic-paretic patterns. Our findings suggest that knee/ankle MS. Personalised profiles clustering algorithms may be promising tools stratifying inform patient-tailored exercise programs. Responsive, objective outcome measures are important monitoring disease progression treatment effects trials.