NRG1 signalling regulates the establishment of Sertoli cell stock in the mouse testis.

摘要: Testis differentiation requires high levels of proliferation progenitor cells that give rise to two cell lineages forming the testis, Sertoli and Leydig cells. Hence defective cycling leads testicular dysgenesis has profound effects on androgen production fertility. The growth factor NRG1 been implicated in adult proliferation, but a potential function fetal testis not analysed date. Here we show Nrg1 its receptors ErbB2/3 are already expressed early gonadal development. Using tissue-specific deletion, further demonstrate is required dose-dependent manner induce then differentiated As result reduced numbers cells, knockout mice display delay defects sex cord partitioning. Taken together signalling essential for establishment stock thus prevent hypoplasia.