Immune suppressive mechanisms in the tumor microenvironment
作者： David H Munn , Vincenzo Bronte
DOI: 10.1016/J.COI.2015.10.009
关键词:
摘要: Effective immunotherapy, whether by checkpoint blockade or adoptive cell therapy, is limited in most patients a key barrier: the immunosuppressive tumor microenvironment. Suppression of tumor-specific T cells orchestrated activity variety stromal myeloid and lymphoid cells. These often display inducible suppressive mechanisms that are triggered same anti-tumor inflammatory response immunotherapy intends to create. Therefore, more comprehensive understanding how milieu develops persists critical order harness full power cancer.
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