Umbelliferone Analogues and Their Potential to Inhibit Benzo(a)pyrene- and Hydrogen Peroxide-Induced Mutations

摘要: Following the natural product lead, farneciferol-D (kopetdaghin, 8), some ether analogues of umbelliferone were synthesized and assayed for their potential to be antimutagenic/anticarcinogenic against mutations induced by benzo(a)pyrene, a potent mutagen/carcinogen, hydrogen peroxide, ability function as free radical scavengers. The "true" antimutagenic effect these compounds was determined at half nontoxic concentration in Salmonella typhimurium strains utilizing modified Ames test protocol, radical-scavenging nonenzymatic phenazine methosulfate (PMS)-NADH system. Umbelliferone 4 5 demonstrated good preventing benzo(a)pyrene peroxide also exhibited superoxide scavenging PMS-NADH assay, suggesting that activity may linked antioxidative properties.