Synthesis and free radical scavenging activity of some new spiropyranocoumarins.

作者: Vassiliki Panteleon , Ioannis K. Kostakis , Panagiotis Marakos , Nicole Pouli , Ioanna Andreadou

DOI: 10.1016/J.BMCL.2008.09.065

关键词:

摘要: A series of novel spiro-substituted 4-hydroxypyranocoumarins and their corresponding dihydropyrano cis-diols has been synthesized. Among them the spiroadamantylpyranocoumarin diols can interact with stable free radical 1,1-diphenyl-2-picrylhydrazyl scavenge superoxide anions generated in xanthine-xanthine oxidase system.

参考文章(39)
Segaran P. Pillai, Sanjay R. Menon, Lester A. Mitscher, Christine A. Pillai, Delbert M. Shankel, Umbelliferone Analogues and Their Potential to Inhibit Benzo(a)pyrene- and Hydrogen Peroxide-Induced Mutations Journal of Natural Products. ,vol. 62, pp. 1358- 1362 ,(1999) , 10.1021/NP990048U
Christos A. Kontogiorgis, Yanan Xu, Dimitra Hadjipavlou-Litina, Yuan Luo, Coumarin derivatives protection against ROS production in cellular models of Aβ toxicities Free Radical Research. ,vol. 41, pp. 1168- 1180 ,(2007) , 10.1080/10715760701447884
Denise Egan, Richard O'kennedy, Elizabeth Moran, Dermot Cox, Ena Prosser, R. Douglas Thornes, The Pharmacology, Metabolism, Analysis, and Applications of Coumarin and Coumarin-Related Compounds Drug Metabolism Reviews. ,vol. 22, pp. 503- 529 ,(1990) , 10.3109/03602539008991449
L. Jurd, J. Corse, A.D. King, H. Bayne, K. Mihara, Antimicrobial properties of 6,7-dihydroxy-, 7,8-dihydroxy-, 6-hydroxy- and 8-hydroxycoumarins Phytochemistry. ,vol. 10, pp. 2971- 2974 ,(1971) , 10.1016/S0031-9422(00)97334-5
Tae-Souk Kang, Hyang-Ok Jo, Woo-Kyu Park, Jong-Pyung Kim, Yasuo Konishi, Jae-Yang Kong, No-Sang Park, Young-Sik Jung, Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides Bioorganic & Medicinal Chemistry Letters. ,vol. 18, pp. 1663- 1667 ,(2008) , 10.1016/J.BMCL.2008.01.061
H. J. KABBE, Eine einfache Synthese von 4-Chromanonen Synthesis. ,vol. 1978, pp. 886- 887 ,(1978) , 10.1055/S-1978-24924
J.R.S. Hoult, Miguel Payá, Pharmacological and biochemical actions of simple coumarins : Natural products with therapeutic potential General Pharmacology-the Vascular System. ,vol. 27, pp. 713- 722 ,(1996) , 10.1016/0306-3623(95)02112-4