Copper‐Mediated Introduction of the CF2PO(OEt)2 Motif: Scope and Limitations
作者： Maria V. Ivanova , Alexandre Bayle , Tatiana Besset , Xavier Pannecoucke , Thomas Poisson
关键词:
摘要: Herein, a general procedure to access CF2 PO(OEt)2 -containing molecules is reported. The reagent CuCF2 accessible by simple protocol and broad range of substrates can be functionalised. allows the conversion aryl diazonium salts, as well aryl, heteroaryl, vinyl alkynyl iodonium into corresponding fluorinated at room temperature. Mechanistic studies were performed gain better understanding reaction pathway. Under similar conditions, iodides, allyl halides, benzyl bromides also functionalised, scope limitations studied. Finally, was extended disulfides offer new SCF2 molecules.
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