Acute and subchronic toxicity and genotoxicity of SE5-OH, an equol-rich product produced by Lactococcus garvieae

摘要: Abstract The consumption of soy-based products is associated with a number health benefits and much these are proposed to be due the soy isoflavones daidzein, genistein, glycitein, their glycosides, equol, an isoflavone naturally produced from daidzein. Equol bacterially-derived metabolite daidzein by bacteria in gut those humans capable hosting particular organism. To allow all enjoy new functional food ingredient has been developed that relies on bacterial conversion equol under strictly controlled conditions. This substance, termed SE5-OH, studied extensively for its acute subchronic toxicity Sprague–Dawley rats, as well potential genotoxicity. oral LD50 >4000 mg/kg. In 91-day, study, no-observed-adverse-effect-level (NOAEL) was 2000 mg/kg/day, highest dose tested. SE5-OH negative Salmonella typhimurium tester strains TA98, TA100, TA1535 TA1537 Escherichia coli strain WP2uvrA without metabolic activation. chromosome aberrations Chinese hamster lung cells up 3000 μg/ml activation did not induce increases micronucleated polychromatic erythrocytes taken rats administered (via gavage) 4000 mg/kg twice daily two consecutive days.