Anitcancer Activity of Vitamin D Analogs

摘要: From its discovery in 1920 to the late 1960s, vitamin D was considered function as a nutritional cofactor for biologic processes related calcium metabolism. Discovery and chemical characterization of plasma metabolites 25-hydroxy D3 [25(OH)D3] 1,25-dihydroxy [1,25(OH)2D3] led recognition true significance precursor hormone, biosynthesis which is tightly regulated, case other steroid hormones (Scheme 1). During last 10 years, significant progress has been made at defining molecular mechanism 1,25(OH)2D3 activity various cellular systems. hormone plays an essential role host involved calcium-phosphate homeostasis, inhibition cell growth, induction differentiation. It now well established that this hormonally active form generates responses by two distinct mechanistic pathways, via regulation gene transcriptions mediated 1,25(OH)2D3-specific nuclear receptors [the receptor (VDR)], nongenomic mode initiated membranes. The genomic effects are especially portrayed multifaceted bone-forming processes, parathyroid release, differentiation myeloid leukemia cells, proliferation large number cancer lines, such breast, prostate, colon. As therapeutic agents, some analogs being used treatment renal osteodystrophy, secondary hyperparathyroidism, osteoporosis, psoriasis, scleroderma. These compounds also have potential be solid tumors based on vivo results discussed chapter. immunosuppressive defined their downregulation interleukin-12 (IL-12), interferon-γ (INF-γ), IL-2 it supported disease suppression models experimental autoimmune encephalomyelitis, diabetes lupus (1).