Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children.
作者： Yang Zhuo , Yalan Yang , Mingjun Zhang , Ying Xu , Zhongping Chen
DOI: 10.1155/2020/8121659
关键词:
摘要: Hepatitis B virus (HBV) infection is a challenging public health problem in China and worldwide. Mother-to-child transmission one of the main routes HBV highly endemic regions. However, mechanisms perinatal children have not been clearly defined. The aim this study was to demonstrate association between single-nucleotide polymorphisms (SNPs) IFN-γ signaling pathway or breakthrough children. Two hundred seventy-four HBV-infected defined as test positive for hepatitis surface antigen (HBsAg) 353 controls negative HBsAg were recruited from October 2013 May 2015. SNPs including IFNG, IFNGR1, IFNGR2, IL12B genotyped. Rs2234711 IFNGR1 significantly associated with (OR = 0.641, 95% CI: 0.450-0.913). In addition, rs2234711 also born HBsAg-positive mothers (OR = 0.452, 0.205-0.998). Our confirmed that genetic variants significant associations infection, especially This provides insight into could be used help design effective strategies reducing immunoprophylaxis failure.
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