Association between IFN-γ genetic polymorphisms and susceptibility to hepatitis B virus infection: A meta-analysis
作者： Yongli Wei , Qing Tian , Lanrong Li , Donghui Zhang
DOI: 10.3109/03014460.2015.1106583
关键词:
摘要: AbstractBackground: Hepatitis B virus (HBV) infection has become a global health burden because of its contagious mode transmission and the resultant long-term liver damage.Aim: To investigate how polymorphisms IFN-γ gene, particularly +874T/A (rs2430561) single nucleotide polymorphism (SNP), influence susceptibility to HBV infection.Subjects methods: Relevant articles were identified by comprehensive literature search covering following computerised bibliographic databases. Eleven independent case-control studies ultimately selected for current meta-analysis, comprising total 1527 cases 1467 healthy subjects.Results: The results in meta-analysis showed that carriers A allele more likely develop than those without all five genetic models (all p A was detected associated with t...
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