Comparative study of the efficacy of transdermal buprenorphine patches and prolonged-release tramadol tablets for postoperative pain control after spinal fusion surgery: a prospective, randomized controlled non-inferiority trial.

摘要: To compare the efficacy of a transdermal buprenorphine patch (5, 10, 15, and 20 μg/h) with that oral tramadol (150, 200, 250, 300 mg) for postoperative pain control after single level spinal fusion surgery. The present study (ClinicalTrials.gov, number NCT02416804) was prospective, randomized controlled non-inferiority trial designed to determine TDS alleviating following patient analgesia (PCA) in persons underwent posterior lumbar interbody surgery through 1:1 allocation. primary outcome Visual Analog Pain Scale (VAS) score back at 7 days non-inferior margin VAS set δ = 1.5 points. (primary outcome) Buprenorphine group not inferior compared Tramadol group. overall changes scores during follow-up assessments over 2-week period did differ between both groups. However, significantly improved time patterns were different medication subacute from 72 h surgery, PCA administration. In addition, adverse events similar