Ly6G+ inflammatory cells enable the conversion of cancer cells to cancer stem cells in an irradiated glioblastoma model.
作者： Hee-Young Jeon , Seok Won Ham , Jun-Kyum Kim , Xiong Jin , Seon Yong Lee
DOI: 10.1038/S41418-019-0282-0
关键词:
摘要: Most glioblastomas frequently recur at sites of radiotherapy, but it is unclear if changes in the tumor microenvironment due to radiotherapy influence glioblastoma recurrence. Here, we demonstrate that radiation-induced senescent cells exhibit a senescence-associated secretory phenotype functions through NFκB signaling microenvironment, such as recruitment Ly6G+ inflammatory and vessel formation. In particular, promote conversion stem (GSCs) NOS2-NO-ID4 regulatory axis. Specific inhibition irradiated glioma using IκBα super repressor prevents dedifferentiation cells. Treatment with Ly6G-neutralizing antibodies also reduces number GSCs prolongs survival tumor-bearing mice after radiotherapy. Clinically, positive correlation exists between axis patients diagnosed recurrent glioblastoma. Together, our results illustrate important roles for recruited by SASP cancer cell
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