Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

摘要: Apoptosis is a form of programmed cell death that results in the orderly and efficient removal damaged cells, such as those resulting from DNA damage or during development. can be triggered by signals within cell, genotoxic stress, extrinsic signals, binding ligands to surface receptors. Deregulation apoptotic machinery an hallmark cancer. alteration responsible not only for tumor development progression but also resistance therapies. Most anticancer drugs currently used clinical oncology exploit intact signaling pathways trigger cancer death. Thus, defects may result drug so limiting efficacy Therefore, better understanding improve therapy bypass resistance. This review will highlight role fundamental regulators apoptosis how their deregulation, including activation anti-apoptotic factors (i.e., Bcl-2, Bcl-xL, etc) inactivation pro-apoptotic p53 pathway) ends up In addition, therapeutic strategies aimed at modulating activity are briefly discussed.