Role of rhinovirus C respiratory infections in sick and healthy children in Spain.

摘要: Background: Recently a new genogroup of human rhinovirus (HRV) has been described and named HRV-C. The relative importance HRV-C in viral respiratory tract illnesses is unknown. Objective: We looked for pediatric patients with infections to determine the incidence its role sick healthy children. describe clinical differences associated other HRV genogroups. Patients Methods: From January 2004 December 2008, prospective study was conducted children younger than 14 years who were admitted infection Pediatrics Department Severo Ochoa Hospital Madrid, Spain. Specimens nasopharyngeal aspirate taken virologic polymerase chain reaction, data recorded. specimens genotyped. studied frequency infections, course these genogroups (HRV-A HRV-B). Presence also group Results: detected 424 1555 episodes illness (27.2%) 26 211 (12.3%) (P 0.001). amplified at random 248 them (227 hospitalized 21 children): 132 (53.2%) had HRV-A, 28 (11.2%) HRV-B, 88 (35.4%) asthma, recurrent wheezing, bronchiolitis but not significantly different from HRV-A genogroup. Nevertheless, significant observed between HRV-B groups: more frequent infiltrate on chest radiograph 0.017), fever 0.052), diagnosis pneumonia 0.01), antibiotic treatment 0.004). Conclusions: diseases bronchiolitis. No found group: both groups.