Modulation of toll-like receptor 8 expression by antisense oligonucleotides

作者: Mallikarjuna Putta , Daqing Wang , Dong Yu , Lakshmi Bhagat , Sudhir Agrawal

DOI:

关键词:

摘要: Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR8. The comprise antisense oligonucleotides targeted to nucleic acids encoding may also TLR8 in combination with other therapeutic and/or prophylactic compounds compositions. Methods using these down-regulating prevention or treatment diseases wherein modulation would be beneficial provided.

参考文章(6)
Jianzhu Chen, Herman N. Eisen, Qing Ge, Rnai-based therapeutics for allergic rhinitis and asthma ,(2005)
Nicholas M. Dean, Frank C. Bennett, Brenda F. Baker, Timothy Vickers, Seongjoon Koo, Stanley T. Crooke, Efficient reduction of target RNA's by single-and double-stranded oligomeric compounds ,(2003)
C WILSON, A KEEFE, Building oligonucleotide therapeutics using non-natural chemistries. Current Opinion in Chemical Biology. ,vol. 10, pp. 607- 614 ,(2006) , 10.1016/J.CBPA.2006.10.001
Y Tang, Chenghua Liu, Vinod Asundi, Chongjun Xu, Ping Zhou, Yunqing Ma, Jian-Rui Wang, Qing Zhao, Feiyan Ren, Rui-Hong Chen, Dunrui Wang, Zhiwei Wang, Tom Wehrman, Jie Zhang, Xiaohong Qian, Radoje Drmanac, Novel nucleic acids and polypeptides ,(2002)
Stephen Bruce Olmsted, William Martin Mounts, Ellen Murphy, Probe arrays for detecting multiple strains of different species ,(2005)