Human toll-like receptor inhibitors and methods of use thereof
作者： Cristiana Guiducci , Karen L. Fearon , Franck Barrat
DOI:
关键词:
摘要: Provided herein are human Toll-like receptor (TLR)-inhibitors and methods for use in individuals having an autoimmune disease or inflammatory disorder. The TLR inhibitors of the present disclosure polynucleotides comprising inhibitory motif one more TLR7, TLR8 TLR9.
lens.org参考文章(119)
CHRISTIAN ENEVOLD, TIMOTHY R.D. RADSTAKE, MARIEKE J.H. COENEN, JAAP FRANSEN, ERIK J.M. TOONEN, KLAUS BENDTZEN, PIET L.C.M. van RIEL, Multiplex Screening of 22 Single-Nucleotide Polymorphisms in 7 Toll-like Receptors: An Association Study in Rheumatoid Arthritis The Journal of Rheumatology. ,vol. 37, pp. 905- 910 ,(2010) , 10.3899/JRHEUM.090775
Sonja I Gringhuis, Michiel van der Vlist, Linda M van den Berg, Jeroen den Dunnen, Manja Litjens, Teunis B H Geijtenbeek, HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells Nature Immunology. ,vol. 11, pp. 419- 426 ,(2010) , 10.1038/NI.1858
PCR – the polymerase chain reaction Analytical Methods. ,vol. 6, pp. 333- 336 ,(2013) , 10.1039/C3AY90101G
Jack S. Cohen, Oligonucleotides as therapeutic agents Pharmacology & Therapeutics. ,vol. 52, pp. 211- 225 ,(1991) , 10.1016/0163-7258(91)90009-B
Grayson B. Lipford, Stefan Bauer, Hermann Wagner, Immunostimulatory g,u-containing oligoribonucleotides ,(2003)
Dipyaman Ganguly, Georgios Chamilos, Roberto Lande, Josh Gregorio, Stephan Meller, Valeria Facchinetti, Bernhard Homey, Franck J Barrat, Tomasz Zal, Michel Gilliet, None, Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8 Journal of Experimental Medicine. ,vol. 206, pp. 1983- 1994 ,(2009) , 10.1084/JEM.20090480
Cristiana Guiducci, Mei Gong, Alma-Martina Cepika, Zhaohui Xu, Claudio Tripodo, Lynda Bennett, Chad Crain, Pierre Quartier, John J. Cush, Virginia Pascual, Robert L. Coffman, Franck J. Barrat, RNA recognition by human TLR8 can lead to autoimmune inflammation Journal of Experimental Medicine. ,vol. 210, pp. 2903- 2919 ,(2013) , 10.1084/JEM.20131044
Daqing Wang, Lakshmi Bhagat, Tao Lan, Sudhir Agrawal, Ekambar R. Kandimalla, Stabilized immune modulatory RNA (SIMRA) compounds ,(2008)
Jörg Vollmer, Sibylle Tluk, Claudia Schmitz, Svetlana Hamm, Marion Jurk, Alexandra Forsbach, Shizuo Akira, Kindra M. Kelly, Westley H. Reeves, Stefan Bauer, Arthur M. Krieg, Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8 Journal of Experimental Medicine. ,vol. 202, pp. 1575- 1585 ,(2005) , 10.1084/JEM.20051696
Cristiana Guiducci, Robert L. Coffman, Tracy Matray, Franck Barrat, Methods and compositions for inhibition of immune responses and autoimmunity ,(2008)