Monomer architecture of tal nuclease or zinc finger nuclease for dna modification
作者： Ting Li , Sheng Huang , Bing Yang
DOI:
关键词:
摘要: The present invention provides compositions and methods for targeted cleavage of cellular chromatin in a region interest and/or homologous recombination at predetermined site cells. Compositions include fusion polypeptides comprising TAL effector binding or zinc finger domain an I-TevI homing endonuclease as well nucleic acid sequence encoding the same. use allows monomer sequences to achieve represents advantage over prior endonucleases which require self-dimerization, two nucleases with appropriate spacers.
lens.org 参考文章(16)
Benjamin Peter Kleinstiver, David Rohan Edgell, Endonuclease for genome editing ,(2012)
George H. Silva, Claudia Bertonati, Jean-Charles Epinat, Julien Valton, Alexandre Juillerat, Philippe Duchateau, Method for the generation of compact tale-nucleases and uses thereof ,(2012)
Sheng Huang, Bing Yang, Ting Li, Nuclease activity of tal effector and foki fusion protein ,(2011)
Yumin Tao, L. Aleksander Lyznik, Huirong Gao, Methods for altering the genome of a monocot plant cell ,(2008)
Qingqing Liu, John T. Dansereau, Shadakshara S. Puttamadappa, Alexander Shekhtman, Victoria Derbyshire, Marlene Belfort, Role of the interdomain linker in distance determination for remote cleavage by homing endonuclease I-TevI. Journal of Molecular Biology. ,vol. 379, pp. 1094- 1106 ,(2008) , 10.1016/J.JMB.2008.04.047
Andrew Scharenberg, Philippe Duchateau, Julianne Smith, Genome engineering with TAL-effector nucleases and alternative modular nuclease technologies. Current Gene Therapy. ,vol. 13, pp. 291- 303 ,(2013) , 10.2174/15665232113139990026
J. Boch, H. Scholze, S. Schornack, A. Landgraf, S. Hahn, S. Kay, T. Lahaye, A. Nickstadt, U. Bonas, Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors Science. ,vol. 326, pp. 1509- 1512 ,(2009) , 10.1126/SCIENCE.1178811
David R Edgell, Victoria Derbyshire, Patrick Van Roey, Stephen LaBonne, Matthew J Stanger, Zhong Li, Thomas M Boyd, David A Shub, Marlene Belfort, Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressor Nature Structural & Molecular Biology. ,vol. 11, pp. 936- 944 ,(2004) , 10.1038/NSMB823
Elena M. Ibryashkina, Giedrius Sasnauskas, Alexander S. Solonin, Marina V. Zakharova, Virginijus Siksnys, Oligomeric Structure Diversity within the GIY-YIG Nuclease Family Journal of Molecular Biology. ,vol. 387, pp. 10- 16 ,(2009) , 10.1016/J.JMB.2009.01.048
David Edgell, Benjamin Kleinstiver, Jason M. Wolfs, Li Wang, Tomasz Kolaczyk, Brendon McDowell, Adam Bogdanove, 102 Genome engineering nucleases derived from GIY-YIG homing endonucleases Journal of Biomolecular Structure and Dynamics. ,vol. 31, pp. 64- 65 ,(2013) , 10.1080/07391102.2013.786344