Temperature-Responsive Biocompatible Copolymers Incorporating Hyperbranched Polyglycerols for Adjustable Functionality

摘要: Temperature-triggered copolymers are proposed for a number of bio-applications but there is no ideal material platform, especially injectable drug delivery. Options needed degradable biomaterials that not only respond to temperature also easily accommodate linkage active molecules. A first step toward realizing this goal the design and synthesis novel materials reported herein. multifunctional macromer, methacrylated hyperbranched polyglycerol (HPG-MA) with an average one acrylate unit per copolymer, was synthesized copolymerized N-isopropylacrylamide (NIPAAm), hydroxyethyl methacrylate-polylactide (HEMAPLA) acrylic acid (AAc). The potential fully exploit by modification multiple HPG hydroxyl groups will be discussed here. Instead, report focuses on thermoresponsive, biocompatible, degradation properties material. Poly(NIPAAm-co-HEMAPLA-co-AAc-co-HPG-MA) displayed increasing lower critical solution temperatures (LCST) as content increased over range macromer ratios. For copolymer maximum incorporation (17%), LCST ~30 °C. In addition, sample showed toxicity when human uterine fibroid cells were co-cultured up 72 h. This lost approximately 92% its mass after 17 hours at 37 Thus, offer attractive delivery systems where orthogonally triggered mechanisms therapeutic release in relatively short time periods would attractive.