Thromboxane Prostanoid Receptor Signals Through Gi Protein to Rapidly Activate Extracellular Signal–Regulated Kinase in Human Airways
作者： Simona Citro , Saula Ravasi , G. Enrico Rovati , Valérie Capra
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摘要: We showed previously that activation of the thromboxane prostanoid (TP) receptor causes human airway smooth muscle (HASM) cells to proliferate, suggesting a role in remodeling. This study aimed at determining molecular mechanisms underlying this mitogenic action. found MEK inhibitor PD98059 significantly affected agonist-induced DNA synthesis HASM cells, which suggests extracellular signal–regulated kinases (ERK) are involved. ERK by agonist U46619 was rapid, sensitive pertussis toxin, and abrogated tyrosine kinase inhibitors genistein PP1. Stimulation TP also translocate phosphorylated into nucleus. activate Ras, as demonstrated inhibition Clostridium sordellii lethal ability increase RasGTP. Finally, [3H]thymidine incorporation phosphorylation were prior treatment with prot...
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