Airway remodeling in asthma.

摘要: Airway remodeling can be defined as changes in the composition, content, and organization of cellular molecular constituents airway wall. is a characteristic feature asthma, has important functional implications. These structural include epithelial detachment, subepithelial fibrosis, increased smooth muscle (ASM) mass, decreased distance between epithelium ASM cells, goblet cell hyperplasia, mucus gland proliferation blood vessels edema cartilage. Each contribute to hyperreactivity (AHR), may eventually lead irreversible airflow obstruction with disease progression. Structural observed from early onset thus thought asthma. Some aspects explained consequence TH2 inflammation, although it also been suggested that exaggerated inflammation seen asthmatic airways abnormal injury repair responses stemming susceptibility bronchial epithelia components inhaled environment. According this view, occurs by way noninflammatory mechanism, where altered structure function are parallel interacting factors. established asthma poorly responsive current therapies, such inhalation corticosteroids administration β2-agonists, antileukotrienes, theophylline.