The audacity of proteomics: a chance to overcome current challenges in schizophrenia research.

摘要: The evidence on the mechanisms underlying schizophrenia seems to support a series of divergent possibilities that may play contributory role in disease pathogenesis. Hypotheses regarding range from structural and neurodevelopmental abnormalities neurotransmitter deficits genetic predisposition. Nevertheless, little progress has been made field with respect key pathophysiological processes, this is fundamental barrier identifying or predicting therapeutic value novel drug targets. All multi-omics approaches, including proteomics, would be perfectly suited such complex as means tackling widening chasm between aforementioned hypotheses. Proteomic studies have performed variety tissues biological fluids, post-mortem CNS tissue cerebrospinal fluid blood, recently generated mutant animal models schizophrenia-like phenotypes. In review, we present an overview s...