The periphery of the human fetal adrenal gland is a site of angiogenesis: Zonal differential expression and regulation of angiogenic factors

摘要: Context: Although the inner fetal zone (FZ) of midgestation human adrenal (HFA) produces dehydroepiandrosterone sulfate, function outer definitive (DZ) remains less clear. We have proposed that DZ phenotype is a pool progenitor cells, many which are mitotically active. Recently, we studied HFA expression family vascular endothelial cell-specific angiogenic factors, angiopoietins (Angs), and demonstrated Ang2 was localized predominantly in periphery gland. Ang1 stabilizes, whereas destabilizes, vessels, increasing responsiveness to stimuli such as growth factor (VEGF)-A fibroblast (FGF)-2. Objective: Our objective test hypothesis site angiogenesis. Design: Studies were conducted involving RNA, frozen sections, primary cell cultures from HFAs. Main Outcome Measures: Immunofluorescence, laser capture microdissection, a...