Geographic and Temporal Trends of Transmitted HIV-1 Drug Resistance Among Antiretroviral-Naïve Subjects Screening for Two Clinical Trials in North America and Western Europe
作者： Sibtain Rahim , Linda M. Fredrick , Barbara A. da Silva , Barry Bernstein , Martin S. King
DOI: 10.1310/HCT1002-94
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摘要: AbstractPurpose: To determine the prevalence of transmitted drug resistance (TDR) in antiretroviral (ARV)-naive HIV-1-infected subjects who were screened for two clinical trials by geographic region and time. Methods: Studies M03-613 M05-730 ARV-naive 2004 2005–2006, respectively. Screening genotype assays performed using population sequencing, mutations (DRMs) was assessed at 39 amino acid positions HIV-1 protease reverse transcriptase (RT) compared between regions calendar years. Results: In 913 subjects, DRMs higher North America than Western Europe, including any DRM (13.6% vs. 6.8%, p < .001), non-nucleoside inhibitor (NNRTI) (7.3% 3.2%, = .006), (PI) (3.6% 0.8%, .004), nucleoside (NRTI) (6.1% 3.8%, ns). The TDR to NNRTIs compar...
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