Ultrastructural effects of irradiation on squamous cell carcinoma of the head and neck.
作者： P. Kellokumpu-Lehtinen , K.-O. Soderstrom , A. Kortekangas , E. Nordman
DOI: 10.1002/1097-0142(19890315)63:6<1108::AID-CNCR2820630612>3.0.CO;2-3
关键词:
摘要: Tissue samples taken before and during the radical irradiation of squamous cell carcinoma head neck region were studied by light electron microscopic examination. Radiation-induced cellular changes which nuclear atypia was most pronounced. The tumor invasion pattern remained unchanged but number mitoses decreased. lymphocytic infiltration increased at beginning therapy (from 10-30 Gy) decreased end radiotherapy. amount neutrofils keratinization almost level, intracellular filaments desmosomes slightly in study. morphologic features pointing a more undifferentiated direction are considered to be due damage rather than aggressive behavior cells. This is agreement with decrease radiation-induced arrest cells G2 phase. These might related disappearance tumors irradiation. leukocyte compartment seen take part destruction removal debris.
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