Factors associated with a good response to lithium in aggressive mentally handicapped subjects

摘要: Abstract 1. Twenty-five (25) mentally handicapped in-patient adults with persistent aggressive behaviour took part in a double-blind crossover trial lasting 5 months comparing the effects of lithium placebo on aspects behaviour. 2. All patients were receiving neuroleptic and/or anticonvulsant drugs which continued during trial. 3. Seventeen (17) showed greater improvement phase compared to placebo. 4. Multiple regression analysis was carried out determine 17 background variables related outcome. 5. The following factors associated good response lithium: less than one episode per week before starting treatment, overactivity, Stereotypic behaviour, female sex and epilepsy. 6. No patient became toxic investigation although levels maintained within therapeutic range (0.5–0.8 mmol/l).