The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer

摘要: // Cecile Naudin 1,2 , Clement Chevalier 1,3 and Serge Roche 1,4 1 CNRS UMR5237, University Montpellier, CRBM, France 2 Present address: INSERM U1016, UMR8104, Institut Cochin, Paris, 3 SFR Biosit (UMS 3480/US 018), MRic Photonics Platform, Rennes, 4 Equipe Labellisee LIGUE 2014, Ligue Contre le Cancer, Correspondence to: Roche, email: Keywords : cell signaling, tyrosine kinase, adaptor proteins, human cancer, cancer therapy Received September 10, 2015 Accepted January 01, 2016 Published 17, Abstract Protein phosphorylation on (Tyr) residues has evolved as an important mechanism to coordinate communication in multicellular organisms. The importance of this process been revealed by the discovery prominent oncogenic properties kinases (TK) upon deregulation their physiological activities, often due protein overexpression and/or somatic mutation. Recent reports suggest that TK signaling is also under control small proteins. These cytosolic proteins lack intrinsic catalytic activity signal linking two functional members a pathway. While most adaptors display positive regulatory functions, group family exerts negative functions targeting several components cascade. Here, we review how these less studied negatively activities loss function induces abnormal promoting tumor formation. We discuss therapeutic consequences novel oncology.