摘要: Ghrelin is an acylated peptide recently isolated from rat and human stomach that potently stimulates GH release in vivo vitro rats humans. specifically activates the receptor for growth hormone secretagogues (GHS) it has been proposed may be endogenous ligand mimicked by these synthetic compounds. primarily produced endocrine cells of stomach, to a lesser extent, other peripheral tissues, including pituitary. Although ghrelin most potent GH-secretagogue so far identified, its circulating levels do not correlate with those either physiological pathological conditions. Because many observations, postulated physiologically involved regulation secretion. Nonetheless, serve as very useful model development more GHS, which therapeutically treatment deficiency.
参考文章(0)