Treg therapy in transplantation: a general overview

摘要: Solid organ transplantation remains the treatment of choice for end -stage failure. Whilst the short term outcomes post -transplant have improved in last decades, chronic rejection and immunosuppressant side effects remain an ongoing concern. Hematopoietic stem cell transplantation is a well -established procedure patients with haematological disorders. However, donor T -cells are continually primed and activated to react against host causing graft -versus -host -disease (GvHD) that leads tissue damages death. Regulatory T -cells (Tregs) play essential role maintaining tolerance self -antigens, preventing excessive immune responses abrogating autoimmunity. Due their suppressive properties, Tregs been extensively studied use as cellular therapy aiming treat GvHD limit responsible graft rejection. Several clinical trials been conducted or currently Accepted Article This article protected by copyright. All rights reserved. ongoing investigate safety feasibility Treg -based therapy. This review summarises the general understanding Treg biology presents methods used isolate expand Tregs. Furthermore, we describe data from first using Tregs, explaining limitations and future application these cells.