OCT-Angiography reveals reduced vessel density in the deep retinal plexus of CADASIL patients.

摘要: Optical coherence tomography angiography (OCT-A) represents the most recent tool in ophthalmic imaging. It allows for a non-invasive, depth-selective and quantitative visualization of blood flow central retinal vessels it has an enormous diagnostic potential not only ophthalmology but also with regards to neurologic systemic diseases. Cerebral autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy (CADASIL) is hereditary vascular small-vessel disease caused by Notch3 mutations common form stroke disorder. In this study, CADASIL patients prospectively underwent OCT-A imaging evaluate choriocapillaris as well at optic nerve head. The vessel density macular region size foveal avascular zone superficial deep plexus were determined head choriocapillaris. Additionally, cerebral magnetic resonance images evaluated. main finding was that significantly decreased compared healthy controls which may reflect pericyte dysfunction capillaries.