Fermentable carbohydrates exert a more potent cholesterol-lowering effect than cholestyramine.
作者： Marie-Laure Favier , Corinne Moundras , Christian Demigné , Christian Rémésy
DOI: 10.1016/0005-2760(95)00107-N
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摘要: The purpose of this work was to assess the respective role bile acid excretion and end-products cecal fermentations in cholesterol-lowering effect complex carbohydrates. effects two different fermentable carbohydrates (guar gum, beta-cyclodextrin), sequestrant resin (cholestyramine) have been investigated male Wistar rats. Guar gum beta-cyclodextrin are broken down large bowel, with fermentation rich propionic (37% against 26% for control), whereas cholestyramine did not enhance fermentation. beta-Cyclodextrin guar were less potent than acids sterol excretion. Nevertheless, exerted a more cholestyramine. also depressed triacylglycerol-rich lipoprotein (TGRLP). Fermentable lowered cholesterol LDL HDL1 fractions. induction hepatic HMG-CoA reductase practically proportional rate fecal steroid Moreover, beta-cyclodextrin, concomitant decrease fatty synthase (FAS) activity. Thus, could be related lipogenesis, as well an accelerated removal HDL1, relation elevated demand cholesterol. In conclusion, favour elimination general lipid-lowering by exerting physiological
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